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Compounds discontinued or likely to have been discontinued from clinical development since 2018 or the previous review [ <xref ref-type= 23 ]" width="250" height="auto" />
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Compounds in, or that have recently completed, phase-II clinical trials (structures in Figs. <xref ref-type= 5 – 7 )" width="250" height="auto" />
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Compounds discontinued or likely to have been discontinued from clinical development since 2018 or the previous review [ <xref ref-type= 23 ]" width="100%" height="100%">

Journal: The Journal of Antibiotics

Article Title: Antibiotics in the clinical pipeline as of December 2022

doi: 10.1038/s41429-023-00629-8

Figure Lengend Snippet: Compounds discontinued or likely to have been discontinued from clinical development since 2018 or the previous review [ 23 ]

Article Snippet: TNP-2198 ( 20 ) , rifamycin-nitroimidazole hybrid b (NP-S) , RNA polymerase , po topical; CDI (TenNor Therapeutics).

Techniques: Inhibition

Compounds in, or that have recently completed, phase-II clinical trials (structures in Figs. <xref ref-type= 5 – 7 )" width="100%" height="100%">

Journal: The Journal of Antibiotics

Article Title: Antibiotics in the clinical pipeline as of December 2022

doi: 10.1038/s41429-023-00629-8

Figure Lengend Snippet: Compounds in, or that have recently completed, phase-II clinical trials (structures in Figs. 5 – 7 )

Article Snippet: TNP-2198 ( 20 ) , rifamycin-nitroimidazole hybrid b (NP-S) , RNA polymerase , po topical; CDI (TenNor Therapeutics).

Techniques: Binding Assay, Activity Assay, Inhibition, Infection

Small molecule antibacterial drugs and β-lactamase inhibitor (BLI) combinations launched from January 2013 to December 2022

Journal: The Journal of Antibiotics

Article Title: Antibiotics in the clinical pipeline as of December 2022

doi: 10.1038/s41429-023-00629-8

Figure Lengend Snippet: Small molecule antibacterial drugs and β-lactamase inhibitor (BLI) combinations launched from January 2013 to December 2022

Article Snippet: TNP-2198 ( 20 ) , rifamycin-nitroimidazole hybrid b (NP-S) , RNA polymerase , po topical; CDI (TenNor Therapeutics).

Techniques:

Compounds in, or that have recently completed, phase-II clinical trials (structures in Figs. <xref ref-type= 5 – 7 )" width="100%" height="100%">

Journal: The Journal of Antibiotics

Article Title: Antibiotics in the clinical pipeline as of December 2022

doi: 10.1038/s41429-023-00629-8

Figure Lengend Snippet: Compounds in, or that have recently completed, phase-II clinical trials (structures in Figs. 5 – 7 )

Article Snippet: TNP-2092 ( 19 ) (CBR 2092) , rifamycin -quinolizinone (ABT719) hybrid b (NP-S) , RNA polymerase, DNA gyrase (GyrA) and Topo IV (ParC) , IV (po topical); ABSSSI, PJI, encephalopathy (TenNor Therapeutics).

Techniques: Clinical Proteomics, Full Display Name, Binding Assay, Membrane, Activity Assay, Disruption, Inhibition, Polymer, Infection